IL-31 Protein, Human
SKU: 95487221873

IL-31 Protein, Human

Sale price$97.20 Regular price$108.00
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Description

IL-31 Protein, HumanProduct Specification Species Human Synonyms IL 31,IL31,Interleukin 31 Accession Q6EBC2 Amino Acid Sequence Ser24 Thr164 Expression System E. coli Molecular Weight 16kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 100mM NaCl, pH6. 5 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.

Product Specification


Species Human
Synonyms IL-31,IL31,Interleukin-31
Accession Q6EBC2
Amino Acid Sequence Ser24-Thr164
Expression System E.coli
Molecular Weight 16kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized Powder
Storage Buffer 20mM PB, 100mM NaCl, pH6.5
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.J Allergy Clin Immunol. 2023 Jul 13;S0091-6749(23)00888-6. Online ahead of print.
2. Allergy. 2023 Jul 13. Online ahead of print.
3. Clin Exp Med. 2023 Jul 1. Online ahead of prin

Background

IL-31 which produced by activated Th2-type T cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.

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Exchange/Return Notes
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SKU: 95487221873

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Candace McCullough
Battle Creek, US
★★★★★ 5
Great chew toy
Color: Blue
I bought this almost a year go. My dog is still chewing on it! Nothing last this long with her. She is a 100lb Rottweiler that is a strong chewer.
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Reviewed in the United States on June 12, 2026
D
Verified Purchase
Dawn Clegg
New York, US
★★★★★ 4
Well loved
Color: Blue, Color: Blue
We just got this sweet girl from the shelter a few days ago. She's had this toy for 2 days and already chomped off one of the legs. She does have other toys so she doesn't play with this one all the time but she does like it a lot! It's very hard and durable on the ends. But as you can see, it's not indestructible. She carries this little guy around the house like they're BFFs. It's super adorable.
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Reviewed in the United States on May 21, 2026
G
Verified Purchase
Greg B.
Cuba, US
★★★★★ 5
Durable and a favorite toy
My 7 month old Black Lab loves this bone. She is a chewer and has gone to town on the three ends. They are roughed up a bit but holding up better than expected. Highly recommend for dogs that love to chew.
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Reviewed in the United States on June 6, 2026
L
Verified Purchase
Lea
Chelsea, US
★★★★★ 5
Perfect for aggressive chewers
I have a 2 year old pittie and she chows thru bones in minutes, even those reviewed as "long lasting". This thing is still going strong after 9 months. She was not initially interested, had to spread peanut butter on one end, one time, and now it is her go-to chew toy. Looks a little mangled after all this time but she's not even 75% thru it. Highly recommend, no stomach issues.
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Reviewed in the United States on June 7, 2026
S
Verified Purchase
Sarah Brannan
Port Orchard, US
★★★★★ 5
Great, durable bone
My dog loves this bone! It’s super durable and has lasted a few months. Keeps my golden busy! Definitely will buy again.
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Reviewed in the United States on June 9, 2026

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