CD30/TNFRSF8 Fc Chimera Protein, Mouse
SKU: 41839580047

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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SKU: 41839580047

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4.3 ★★★★★
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luvAmazon?
Charlottesville, US
★★★★★ 5
High quality, durable, loved by my chewer *
Size: Medium (Pack of 1), Style: Stick Medium
Excellent chew bone Toy for aggressive chewer. I've purchased this same brand bone/ Toy for several years. One lasts at least 1-2 years ( if it doesn't get run over by a lawn mower). Lol. I usually pay $8-$9 for one in retail stores. This is an excellent price at $6. Squeaker stops after a few months but my Field Spaniel dog is deaf now anyway! He loves chewing on this for his gums and when people are gathered in the same room he just starts chewing and enjoying himself in the midst of fellowship.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 31, 2024
T
Verified Purchase
Tiffany
Birmingham, US
★★★★★ 1
Not for aggressive chewers
Size: Large (Pack of 1), Style: Stick Large, Size: Large (Pack of 1), Style: Stick Large
I got this for my 95lb lab who is an aggressive chewer thinking that it looked durable and would last a while. He tore it apart within an hour and I had to throw it away.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026
E
Verified Purchase
E
Los Angeles, US
★★★★★ 3
Felt durable but it couldn’t hold up
Size: Large (Pack of 1), Style: Stick Large, Size: Large (Pack of 1), Style: Stick Large
I really thought my pet wouldn’t be able to destroy it but it’s in tiny pieces in the trash now. we played together and she was gentle I guess because she didn’t bite or tug hard at all I left her alone with it like I’ve done before but this time she broke it down in chunks. Did not have this toy for more then 24 hours.
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Reviewed in the United States on January 20, 2025
E
Verified Purchase
ELM
Cuba, US
★★★★★ 5
Can be tossed around indoors
Size: Large (Pack of 1), Style: Stick Large
Flexible stick toy. Dogs enjoy carrying it around. Squeaks. We have had one for years. It is still in great shape but bought 2 more as I have 3 dogs and all enjoy them. I can toss this in the house.
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Reviewed in the United States on May 18, 2026
C
Verified Purchase
Christyanne748
Fort Morgan, US
★★★★★ 5
Great fun & strong!!!
Size: Large (Pack of 1), Style: Stick Large
These are the best sticks ever! Our dogs chew and slobber all over these for sometimes an hour at a time. They like the “give” texture when they chew it. Imagine an indestructible, gummy bear! Because of their softness, they don’t end up with sharp edges or texture, although they are sturdy, and very durable. We have had these for our two dogs for close to a month now and it is their go to indoor to stick. The gentle squeak is not loud and obnoxious, but a playful sound that has them coming back for more with each chomp! If you love your dogs, this is the cheese stick for them. He’s also make an excellent fetch stick as they can go inside or outside. They wash off easily with water. This is a great investment, especially if you’ve been wasting your money replacing toys for strong jawed dogs!
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Reviewed in the United States on March 22, 2023

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