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Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
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Description
p16 Recombinant Rabbit mAb (S-303-1)Product Specification Host Rabbit Antigen p16 Synonyms Cyclin dependent kinase inhibitor 2A, Cyclin dependent kinase 4 inhibitor A (CDK4I), Multiple tumor suppressor 1 (MTS 1), p16 INK4a (p16 INK4; p16INK4A), CDKN2A, CDKN2, MTS1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P42771 Clone Number S 303 1 Antibody Type Recombinant mAb Application WB, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | p16 |
| Synonyms | Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A (CDK4I), Multiple tumor suppressor 1 (MTS-1), p16-INK4a (p16-INK4; p16INK4A), CDKN2A, CDKN2, MTS1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P42771 |
| Clone Number | S-303-1 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| ICC | 1:100 | null |
| ICFCM | 1:500 | null |
Background
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.7 ★★★★★
Based on 2074 reviews
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Product Reviews
★★★★★ 4
Built-in USB-C solves the power issue, but it is strictly for moderate chewers
Color: Blue
Got this to keep the high-energy puppy occupied indoors so the older dogs can actually get some peace and quiet. The main issue with most automated electronic pet toys is that they rely on expensive, hard-to-find button cell batteries that die after a single afternoon of use.
This unit utilizes a built-in 300mAh battery with a standard Type-C charging interface. That is a mandatory design feature if you actually want to run the toy daily without going broke replacing power cells. The internal motor generates enough erratic movement to keep a dog's attention, and it actually has the torque to navigate over standard tile, hardwood, and light carpets without instantly stalling out in a corner.
You need to completely understand the physical limitations of what you are unboxing here. The listing explicitly states this is not for heavy chewers, and you need to take that warning seriously. The outer shell is TPU, but the internal chassis housing the electronics is hard ABS plastic. If you hand this to an 80-pound working dog that aggressively shreds thick bones, they are going to crush the housing and destroy the internal motor assembly in about ten minutes.
At roughly 2.5 inches in diameter, it's basically the size of a standard tennis ball. If you use it as intended—as an interactive chasing toy for a puppy or a moderate chewer rather than a heavy-duty chew toy—it functions perfectly. It is a highly practical piece of indoor enrichment gear. Solid return on investment for burning off excess canine energy.
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Reviewed in the United States on May 29, 2026
★★★★★ 5
Pawsitively Stimulating🐾
Color: Blue
When my hooman brought this home, I thought it was fur their computer. After all, it has a plug and lights up. When they placed it on the floor, I was pawsomely surprised. Fur real, this little ball is wierd. It doesn't taste at all like my favorite tennis ball. I was a pawplexed that sometimes when I was finally brave enough to get it and hold it in my mouth, it would start jumping around. I think my hoomans finally found a toy that will keep me busy for a while. Mom is howling with excitement because it kept me interested for a long time. I hope I can sleep tonight. I see mom has plugged in my new toy to keep it "charged"- whatever that means....I never had a toy that came with its own leash before. Mom says she is gonna save the toy until other hoomans come over to keep me from being too ruff with them. You see the video, do I look a dog who could be too ruff?- Sincerely, the family dog, a bona-fido toy reviewer
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Reviewed in the United States on May 3, 2026
★★★★★ 4
Freaks my dogs out.
Color: Blue, Color: Blue
My dogs really don't know what to make of these. They mostly follow it around, staring at it curiously, but semi-afraid to approach it. That, or they'll bark at it. It charges quickly and has multiple modes to engage your pet with. It also locks closed securely ... for the most part.
That said, there are some downsides. This toy is mostly made for smaller dogs. I'd say 40 or 50 pounds max. While the plastic shell feels hard and durable, it's not hard enough for a big dog's jaws. My big bulldog mix bore down on this with his teeth, and I hard the plastic starting to snap. It's tough, but not great if your dog is the type who likes to put the pressure on.
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Reviewed in the United States on May 4, 2026
★★★★★ 5
Best money for a dog toy I've spent in a long time
Color: Blue
This interactive ball is small but packs a lot of fun and playtime for my dog's they go crazy every time we bring it out and turn it on, it lights up has several modes vibrates they love it will be purchasing amount for certain
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Reviewed in the United States on May 9, 2026
★★★★★ 4
Fun, engaging dog toy that keeps pets entertained, but battery life could be better
Color: Blue
I’ve been using the ITEHZTO Interactive Dog Ball Automatic Dog Toy for my dog, and overall it’s been a great way to keep him active and engaged, especially when I’m busy or not able to play fetch. The different play modes are a nice feature, and the unpredictable movement really grabs his attention. It does a good job of encouraging exercise and mental stimulation.
The USB-C charging is convenient, and I appreciate not having to mess with batteries. The size is also good for small to medium dogs, and it feels durable enough to handle regular play.
The reason I’m giving 4 stars instead of 5 is that the battery life doesn’t last as long as I expected, especially when using the more active modes. Also, on harder flooring it can be a bit noisy as it bounces around.
Overall, it’s a fun and useful interactive toy that my dog genuinely enjoys. With slightly longer battery life and quieter operation, it would easily be a 5-star product.
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Reviewed in the United States on May 6, 2026